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MYP_010339
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Basic Information
Brevinin-1VLe
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C126H205N27O27S2
Standard
Sequence
FLPLIAGVAASILPKIFCFITKKC
Physicochemical Analysis
2594.27 Da
9.39
2.74
2.50
0.1141
1.48
0.57
0.49
30.12
138.33
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
833.56
-1.42
30.0
32.0
82.0
182.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0174201 VERIFIED: YES
Provenance & Taxonomy
Rana vaillanti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
5000 μM
LC50
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
RECORD: Rec_0178362 VERIFIED: YES
Provenance & Taxonomy
Rana vaillanti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic Anticancer
HepG2 hepatoma-derived cells
7000 μM
LC50
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
RECORD: Rec_0185279 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anticancer
Candida albicans
3 μM
MIC
RECORD: Rec_0211740 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anticancer Anti-Gram-positive
Staphylococcus aureus
3 μM
MIC
RECORD: Rec_0234899 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
100.0 μM
MIC
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 150 (2009) 150-154. Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
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