Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length737 amino acids

Chemical FormulaC3582H5681N1007O992S22

DescriptionStandard

        MVTGCSSPGLGISPSAGWSVGRGPLQAQERAEKQSGLAGEGRPGTQGESPTEPARRDWRQGEARGGPRAAAGAGRSAAPRAGRGGATAAPLWRRLARAPPAAREDKQAPRSRPGAAPPPRAAGPPAAFPPAALGHAARPPRPHRRPGQAPAPAPHPRLDFGSLQKLSLAQIQWLQCEKRAFYQPHTQVGFHPRAKIASFWKPCKIAAVLPLSRPHPFPSSFLHPTGLRFPSQVLYRSLAPLQGLQALAASENEDMAREPDSVLRWAALLVLATLGTAVMAATNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPDFSGSFKIKHLGKGHYSFYSMVVRGFQLPSSQIRLVPNKGLDVSIINANMKISGKWKARKKFIKAKGNFDLSVTGISISAGLELGFDPASGLPTATCSSCSNHINSVRVHISGGKMGWLIQLFHKKIESSIRNTMTSKICQIVTSSVSSKLQSYLKTLRVTTKIDKVAGINYSLVAPPTATADNLDGQLKGEFFSVAHPGPFPFTSPALAFPNDHDRMVYLGISDYFFNTAGFVYQQAGVLHLTITDDMIPKKSKFRLTTTFLGTLIPEVAKMFPNMMVQLNISASSPPHLTVLPTGLIFTPALEIQAFAVLPNSSLASLFVLHLNTNASMEVSATADRLVGKLSVDRLLLELKHSDIGPFSVVVLQAIMNYVLSTTVIPRINEWLMKGFPLPLPANVQLFNLVLQSHQNFLLFGADVHYS
    

Molecular Weight79430.01 Da

Isoelectric Point (pI)10.14

Net Charge (pH 7.0)38.21

Net Charge (pH 7.4) 36.75

Charge Density (pH 7.0) 0.0518

GRAVY Index-0.07

Hydrophobic Moment 0.77

Boman Index0.08

Instability Index44.76

Aliphatic Index 87.57

Aromaticity 0.0760

Extinction Coeff. Reduced 67380.00

Extinction Coeff. Oxidized 67755.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0218149 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinus ursinus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence