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MYP_010301
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Basic Information
Interferon-induced transmembrane protein 2
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
144 amino acids
C710H1103N181O207S8
Standard
Sequence
MSHNSQAFLSTNAGLPPSYETIKEEYGVTELGEPSNSAVVRTTVINMPREVSVPDHVVWSLFNTLFFNACCLGFVAYAYSVKSRDRKMVGDVVGAQAYASTAKCLNISSLIFSILMVIICIIIFSTTSVVVFQSFAQRTPHSGF
Physicochemical Analysis
15742.96 Da
6.81
-0.27
-0.72
-0.0019
0.40
0.49
0.21
44.05
93.33
0.1111
12950.00
13200.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
6164.57
-61.75
219.0
218.0
504.0
1106.0
26.0
154.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0174813 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
IFITM
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Ser19
Bio-Activity Profile
Antiviral Entry inhibitor Anti-EBOV
Ebola virus (EBOV)
pseudovirus entry inhibition assay (GFP flow cytometry)
PaperDistinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PMID21253575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21253575/
RECORD: Rec_0177127 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
IFITM
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Ser19
Bio-Activity Profile
Antiviral Anti-IAV
Influenza A virus (IAV)
pseudovirus entry inhibition assay (GFP flow cytometry)
PaperDistinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PMID21253575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21253575/
RECORD: Rec_0410482 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
IFITM
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Ser19
Bio-Activity Profile
Antiviral Entry inhibitor
SARS-CoV
pseudovirus entry inhibition assay (GFP flow cytometry)
PaperDistinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PMID21253575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21253575/
RECORD: Rec_0431831 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
IFITM
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Ser19
Bio-Activity Profile
Antiviral Replication inhibitor Anti-EBOV
Ebola virus (EBOV); Vero E6 cells; A549 cells
infectious virus replication assay (viral titer by quantitative RT-PCR)
PaperDistinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PMID21253575
RECORD: Rec_0431832 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
IFITM
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Ser19
Bio-Activity Profile
Antiviral Replication inhibitor Anti-SARS-CoV
SARS-CoV; Vero cells
infectious virus replication assay (plaque assay)
PaperDistinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PMID21253575