Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length417 amino acids

Chemical FormulaC2054H3222N508O599S18

DescriptionStandard

        MLLSVTVVLGLLSCVCGENPAVQVVLTNKGLQYGKHEAAGWIQERLSKITFPDITGSVHIIFGNVDYTLTGITIVKCDLPEPSVEFLQNPPGFQTTISDLSIAITGDWRTHFGLIHDGGTFDMAIYNVDVTSVAQLGKEADGHPSVSSLSCHSQVGDVDIEFHGGASFIFQPFVKHFKGRIRDEIQKRLCPGVEGNIQSFEDHLHVMNVSVDVNEVLTLALPLTDVPIIGASGMNVGLKGEFYNIKTPVEPPFEAQPFTMPDEPSYMLSVGMSDFTLNSASYAYFSAKLLQLLITDSMIPPISPVHLNTTSLGKFIPKLAEMYPDMLMSVLVYAQEAPKFSIQPDAINVSIKAVAKASVILPNGTQIPVFTINVVSTFVCWTFAVLTMLSLGLISNVTLTLASSEVGTFKVNVPKIK
    

Molecular Weight45193.77 Da

Isoelectric Point (pI)5.15

Net Charge (pH 7.0)-13.56

Net Charge (pH 7.4) -14.50

Charge Density (pH 7.0) -0.0325

GRAVY Index0.30

Hydrophobic Moment 0.64

Boman Index0.23

Instability Index36.50

Aliphatic Index 102.76

Aromaticity 0.0839

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30285.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0272939 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis niloticus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence