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MYP_010272
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Basic Information
LL-37 (17-29) [F27L]-Ac
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C77H137N25O17
Standard
Sequence
FKRIVQRIKDLLR
Physicochemical Analysis
1685.07 Da
11.72
3.76
3.55
0.2892
-0.36
0.96
-0.40
24.50
142.31
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
730.65
-3.91
27.0
21.0
61.0
119.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015355 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
μg/ml
200 μg/mL
Cytotoxicity
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0084288 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
75 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0133510 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
μg/ml
500 μg/mL
Hemolysis
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0251128 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
75 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0252681 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
45.5 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
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