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MYP_010254
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Basic Information
Pituitary adenylate cyclase-activating polypeptide-27
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
27 amino acids
C142H223N39O40S
Standard
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVL
Physicochemical Analysis
3148.59 Da
9.70
2.84
2.58
0.1053
-0.41
0.44
-0.10
23.96
75.93
0.1481
4470.00
4470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1309.76
-11.56
48.0
45.0
105.0
222.0
5.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0099854 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Glucagon
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Metabolic
PMID1720095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1720095/
RECORD: Rec_0112867 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
PACAP
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
D-residue notation at positions 2
Bio-Activity Profile
Neuroprotective
0.0103±0.0021 μM
IC50
DPP IV, in vitro; >14400 s
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
RECORD: Rec_0124508 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Blood-Brain Barrier
PaperBrainpeps: the blood-brain barrier peptide database PMID22205159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22205159/
RECORD: Rec_0125178 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Pituitary adenylate cyclase-activating polypeptide
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory
secretion by pancreatic beta cells
Experimental: 39±4 minutes; /2340 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
RECORD: Rec_0134404 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]
Pituitary adenylate cyclase-activating polypeptide
8554
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation
Experimental: 39±4 minutes; /2340 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperNovel stable PACAP analogs with potent activity towards the PAC1 receptor PMID18353507 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18353507/
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