Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length498 amino acids

Chemical FormulaC2418H3892N648O697S18

DescriptionStandard

        MRLSSSFILGSCEPERARWDRITQDSTTQVSQSANPGVKVKLTQKGLEYGRQIGMATLQSKLKSIKVPDMSGTEKVSPIGKVKYSLTGMEIVNLGLPKSSVGLVPGTGPALPEGPAPHQSSGARRTGMTNVFPRSFFLPKCRKDSGSFELAVSGLTITAQIALKSDETGRPTVSSANCVANVGNANIKFHGGASWLYNLFRSSIGKALRKAIEQQICPLVAEAISELNPHLKTLNVLAQVDKYAEIEYSMVTPPAISKASIDFGLKGEFYNIGKHQEPPFAPSPFSLPAQSTNMLYIGVSSFTTNSAGFVYNNAGALSLYITDDMIPRTSPIRLNTRTFGAFIPEIAKRFPNLMMKMLVRTTKPPVITFQPDNVTLQAIGTVTAYAIQLNGTLEPLFILNLNASVSARVYISGLKVAGSVALNSFGMTLGTSYVGPFQVKSLDNILLLVLKVAVLPRVNARLQQGYPLPAIGKMNLVKPQLRVLKDYMLIGTDVHFTP
    

Molecular Weight53769.86 Da

Isoelectric Point (pI)9.78

Net Charge (pH 7.0)20.91

Net Charge (pH 7.4) 20.28

Charge Density (pH 7.0) 0.0420

GRAVY Index0.03

Hydrophobic Moment 0.76

Boman Index0.11

Instability Index43.49

Aliphatic Index 94.18

Aromaticity 0.0743

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0097658 VERIFIED: YES

Provenance & Taxonomy

OrganismAlbula glossodonta [Animal]

FamilyBPI LBP Plunc super, BPI LBP

Tax ID121402

Structure & Mods

Configgene-encoded linear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria