Peptide Database

Peptide NameSLAY-screened peptide P2958

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC101H145N29O34S2

DescriptionStandard

        FLRCYDCYNDHTASDNSHVL
    

Molecular Weight2373.54 Da

Isoelectric Point (pI)5.13

Net Charge (pH 7.0)-2.08

Net Charge (pH 7.4) -2.42

Charge Density (pH 7.0) -0.1042

GRAVY Index-0.59

Hydrophobic Moment 0.48

Boman Index-0.09

Instability Index27.20

Aliphatic Index 58.50

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1034.71

LogP -11.89

H-bond Donors 38.0

H-bond Acceptors 36.0

Rotatable Bonds 73.0

Heavy Atoms 166.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0144926 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/