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MYP_010054
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
6 amino acids
C34H55N7O7
Standard
Sequence
IPAVFK
Physicochemical Analysis
673.84 Da
8.75
0.76
0.55
0.1265
1.30
0.60
0.48
10.58
130.00
0.1667
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
226.05
0.42
7.0
8.0
19.0
48.0
2.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001230 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Lactoglobulin-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-IV inhibitory Antidiabetic
Dipeptidyl peptidase-IV (DPP-IV)
143 μM
IC50
PaperDipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in β-lactoglobulin | Silveira, ST. et al. | DOI: 10.1016/j.foodchem.2013.03.056 Evidence URLhttps://www.uniprot.org/uniprotkb/P02754/entry
RECORD: Rec_0049124 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Lactoglobulin-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cell-proliferative Growth-promoting Lymphocyte-proliferative Immunomodulatory
Murine splenocytes
Cell proliferation assay
PaperProliferative effects of synthetic peptides from β-lactoglobulin and α-Lactalbumin on murine splenocytes | Jacquot, A. et al. | DOI: 10.1016/j.idairyj.2010.02.013 Evidence URLhttps://www.uniprot.org/uniprotkb/P02754/entry
RECORD: Rec_0082271 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Lactoglobulin-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis
Bacterial kill assay (log(N0/Nf))
PaperPlasmin-digest of β-lactoglobulin with antibacterial properties | Sedaghati, H. et al. | DOI: 10.1080/09540105.2014.893998 Evidence URLhttps://www.uniprot.org/uniprotkb/P02754/entry
RECORD: Rec_0187715 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPellegrini A., Dettilng C., Thomas U., Hunziker P.. Isolation and characterization of four bactericidal domains in the bovine beta-lactoglobulin. Biochim. Biophys. Acta, 1526, 131-140, 2001.
RECORD: Rec_0188974 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
144.8
IC50
PaperO. Power, A. Fern¨¢ndez, R. Norris, F.A. Riera, R.J. FitzGerald. Selective enrichment of bioactive properties during ultrafiltration of a tryptic digest of beta-lactoglobulin, J. Funct. Foods 9 (2014) 38-47.
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