Peptide Database

Peptide NameTRAIL

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length281 amino acids

Chemical FormulaC1447H2240N390O435S14

DescriptionStandard

        MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
    

Molecular Weight32508.53 Da

Isoelectric Point (pI)7.01

Net Charge (pH 7.0)0.01

Net Charge (pH 7.4) -0.67

Charge Density (pH 7.0) 0.0000

GRAVY Index-0.48

Hydrophobic Moment 0.65

Boman Index-0.04

Instability Index42.58

Aliphatic Index 76.62

Aromaticity 0.1139

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0251636 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Receptor agonist Immunomodulatory Signaling peptide

Targetdeath receptor 4 (Human); death receptor 5 (Human)

Activity59 nM

MethodKd