Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2406H3815N629O672S16

DescriptionStandard

        MFNPSHSRARRSLKMLWVLVMLLGIRTEALAPGIKAEITLKGLDYGKEVGMEFLNSALLKLSIPDLKGSYSIPLVGPVEWAMTGFQVKALNLGESLIAFVPNSGLKLSMGPAEAEVDGHWSVVASLIRDSGTLSLNVRDVTLAVQVGVHWNGAGRLVVSSEGCSSHIGRLEVTFHGGASWLYNIFFEVLEDLIRKQLNSKLCESIGNAVQTLERTLQTIPESRHISPLADLNCSLVAAPLIMEQSIELDFKGEFYSPASHKEFPVPPAPFSLWKQNDHMLLLGVSDFVANSAAFVYYQAGALSRTFNDSQIPKWFPIRLNTKNFKNFVPELQKRFPNTTMALKIFARLPPRLQSQSGALKVVLPGALQAFVLPKGNSAVPVFLLDMDTEASGQVFASGKNIGASLKLTNFSLTLAHSDVGPFQVDKLEMLMNVALKLVILPKINRKLKNGFPLPTLPKASLQDMVINIEEGFLAIATDVHYGA
    

Molecular Weight52817.88 Da

Isoelectric Point (pI)8.76

Net Charge (pH 7.0)4.39

Net Charge (pH 7.4) 3.52

Charge Density (pH 7.0) 0.0091

GRAVY Index0.16

Hydrophobic Moment 0.77

Boman Index0.15

Instability Index38.41

Aliphatic Index 104.58

Aromaticity 0.0828

Extinction Coeff. Reduced 48930.00

Extinction Coeff. Oxidized 49055.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0117943 VERIFIED: YES

Provenance & Taxonomy

OrganismMonodelphis domestica [Animal]

FamilyBPI/LBP

Tax ID13616

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria