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MYP_009930
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
13 amino acids
C75H123N15O15
Standard
Sequence
FFGSVLKLIPKIL
Physicochemical Analysis
1474.87 Da
10.00
1.76
1.55
0.1352
1.51
0.65
0.52
2.24
172.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
476.00
0.98
16.0
17.0
48.0
105.0
3.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0249229 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 7 and 11) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (7) and Ⓚ (11) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
64 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0263070 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0271517 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 7 and 11) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (7) and Ⓚ (11) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Listeria monocytogenes
4 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0276604 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 7 and 11) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (7) and Ⓚ (11) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus BNCC 186335
4 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0299368 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylarana picturata [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antiviral
Escherichia coli
25 μM
MIC
PaperCharacterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae). PMID18621071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18621071/
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