Peptide Database

Peptide NameSLAY-screened peptide P676

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC105H150N22O32S

DescriptionStandard

        ECSATYAVPGDQYPNYFILL
    

Molecular Weight2264.51 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.17

Net Charge (pH 7.4) -2.36

Charge Density (pH 7.0) -0.1087

GRAVY Index0.11

Hydrophobic Moment 0.28

Boman Index0.27

Instability Index64.97

Aliphatic Index 83.00

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 860.57

LogP -6.04

H-bond Donors 29.0

H-bond Acceptors 31.0

Rotatable Bonds 65.0

Heavy Atoms 160.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0231888 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/