Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length502 amino acids

Chemical FormulaC2506H4024N656O711S21

DescriptionStandard

        MVSFTQCCCQLASRQFKHPDRKRPSIGTSQQFKIIVLEMMFLWCVLVLVNLVSVATDTNAGDKVRITQKGLEYGRQIAIASIQQKLRTIQLQDISGTERVKAVGKVQYSFTGMQVVNLGLPKSALRLVPGTGVMLSIDNVYINLRGNWRVKYLRIIRNSGSFDLAVSELTISTTIAITSDNTGRPMVSVTNCAATVGSVNVKFHGGASWLYNLFRSFINKALRNALQKKICPLVIRSIADTNPHLKTLNGDMINYVLITVLAKVDQYAEIEYSMVGSPVISNTFIDLGLKGEFYNIGQHKEPPFSPKPFSLPTQDTKMLYFGISAFSINSAGFVYQTAGVLRLSITDDMIGKMYPDLMVKLLVETVKEPLVTFEPNNMTVQASSTVTAYAIQPNSTLSPLFVLNLEGSVSAHIYVTELKLAGNVTLNKFKMSVAESYVGPFQVAFLDTIFTVVLRVAVLPLVNARLREGFPLPAIGKMQLVNSQLQVLKDYLLIGTDVQFNG
    

Molecular Weight55392.09 Da

Isoelectric Point (pI)9.44

Net Charge (pH 7.0)14.89

Net Charge (pH 7.4) 14.24

Charge Density (pH 7.0) 0.0297

GRAVY Index0.21

Hydrophobic Moment 0.74

Boman Index0.14

Instability Index29.37

Aliphatic Index 105.94

Aromaticity 0.0857

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0190088 VERIFIED: NO

Provenance & Taxonomy

OrganismLabeo rohita [Bacterium]

FamilyBPI

Tax ID84645

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence