Peptide Database

Peptide NameSLAY-screened peptide P4619

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC91H150N28O31S2

DescriptionStandard

        NQPTSQRHECIDSAALPIIC
    

Molecular Weight2196.46 Da

Isoelectric Point (pI)5.32

Net Charge (pH 7.0)-1.17

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0584

GRAVY Index-0.24

Hydrophobic Moment 0.35

Boman Index-0.01

Instability Index75.85

Aliphatic Index 88.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 953.78

LogP -11.95

H-bond Donors 33.0

H-bond Acceptors 33.0

Rotatable Bonds 69.0

Heavy Atoms 152.0

Ring Count 3.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0394392 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/