Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length188 amino acids

Chemical FormulaC970H1502N232O267S10

DescriptionStandard

        MPVKVYADKIAGINYSLVAAPKIMTHGLFIPLKGQFFSLTNPSKHAFSPSVMKIPEDNHRMIYFAVSPYFFDSAKQVYQDAGIKSLKMTNEMVPKDSKFPLTTKVYGTLIPQVSKNFPNMKMQFILDMPSIPSIIITSKNNTSFMSSISTQAYAIFPNSSLAPLFRISLAPSELESLIYWQFPGVSTT
    

Molecular Weight21006.35 Da

Isoelectric Point (pI)9.55

Net Charge (pH 7.0)6.76

Net Charge (pH 7.4) 6.34

Charge Density (pH 7.0) 0.0359

GRAVY Index0.07

Hydrophobic Moment 0.58

Boman Index0.17

Instability Index39.08

Aliphatic Index 84.04

Aromaticity 0.1223

Extinction Coeff. Reduced 17420.00

Extinction Coeff. Oxidized 17420.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7883.62

LogP -91.68

H-bond Donors 265.0

H-bond Acceptors 287.0

Rotatable Bonds 675.0

Heavy Atoms 1479.0

Ring Count 44.0

Amide Bonds 203.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0292830 VERIFIED: NO

Provenance & Taxonomy

OrganismMonodelphis domestica [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence