Peptide Database

Peptide NameSLAY-screened peptide P5462

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC80H134N34O23S

DescriptionStandard

        DPRVANRGRQRLMEHH
    

Molecular Weight1972.20 Da

Isoelectric Point (pI)11.52

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.63

Charge Density (pH 7.0) 0.1211

GRAVY Index-1.79

Hydrophobic Moment 0.64

Boman Index-0.64

Instability Index6.68

Aliphatic Index 48.75

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 956.77

LogP -11.25

H-bond Donors 34.0

H-bond Acceptors 28.0

Rotatable Bonds 66.0

Heavy Atoms 138.0

Ring Count 3.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0205753 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/