Peptide Database

Peptide NameTP1[C7A,C12S]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC99H154N34O21S2

DescriptionStandard

        KWCFRVAYRGISYRRCR
    

Molecular Weight2220.63 Da

Isoelectric Point (pI)10.90

Net Charge (pH 7.0)5.74

Net Charge (pH 7.4) 5.50

Charge Density (pH 7.0) 0.3375

GRAVY Index-0.75

Hydrophobic Moment 0.68

Boman Index-0.45

Instability Index13.22

Aliphatic Index 45.88

Aromaticity 0.2353

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 940.92

LogP -7.33

H-bond Donors 40.0

H-bond Acceptors 29.0

Rotatable Bonds 71.0

Heavy Atoms 156.0

Ring Count 5.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0350491 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetBacillus subtilis ATCC 6051

Activity0.25 μg/mL

MethodMIC

RECORD: Rec_0408148 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetBacillus subtilis ATCC 6051(MIC=0.25 Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 μg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=2 μg/ml);; Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.5 μg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.5 μg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=4 μg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=2 μg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=16 μg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 μg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 μg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=2 μg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=4 μg/ml);; Fungi : Candida albicans ATCC 90028(MIC=8 μg/ml), Cryptococcus neoformans ATCC 208821

Activity0.5 μg/mL

MethodMIC

RECORD: Rec_0410975 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

RECORD: Rec_0419817 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetP.aeuroginsa FADDI-FAO70

Activity4 μg/mL

MethodMIC

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