Peptide Database

Peptide NameAdrenomedullin

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length52 amino acids

Chemical FormulaC262H404N78O77S3

DescriptionStandard

        YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDGVAPRSKISPQGY
    

Molecular Weight5974.68 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)4.82

Net Charge (pH 7.4) 4.53

Charge Density (pH 7.0) 0.0928

GRAVY Index-0.83

Hydrophobic Moment 0.64

Boman Index-0.17

Instability Index44.22

Aliphatic Index 45.00

Aromaticity 0.1346

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2569.12

LogP -30.33

H-bond Donors 91.0

H-bond Acceptors 86.0

Rotatable Bonds 199.0

Heavy Atoms 420.0

Ring Count 10.0

Amide Bonds 59.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0114259 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyAdrenomedullin

Tax ID9823

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide16-21

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Vasoconstrictor Cardiovascular Growth regulation Development regulation Receptor modulation

Half-LifeMammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min