Peptide Database

Peptide Namegrowth/differentiation factor-1

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length119 amino acids

Chemical FormulaC555H866N164O156S9

DescriptionStandard

        DAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR
    

Molecular Weight12620.40 Da

Isoelectric Point (pI)6.97

Net Charge (pH 7.0)-0.03

Net Charge (pH 7.4) -0.50

Charge Density (pH 7.0) -0.0003

GRAVY Index0.17

Hydrophobic Moment 0.68

Boman Index0.12

Instability Index57.94

Aliphatic Index 88.57

Aromaticity 0.0756

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5002.54

LogP -49.92

H-bond Donors 178.0

H-bond Acceptors 168.0

Rotatable Bonds 391.0

Heavy Atoms 884.0

Ring Count 24.0

Amide Bonds 125.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0210159 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThe active peptide is a homodimer linked by a disulphide bond between cysteine residues at position 83 of each chain. Disulphide bond formation between cysteine residues at positions 14 and 84, 43 and 116, and 47 and 118

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetGrowth/differentiation factor receptors (Human)