Peptide Database

Peptide NameMT-SC31EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC188H301N47O61S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIKKSEEQQKKNEK
    

Molecular Weight4227.74 Da

Isoelectric Point (pI)5.37

Net Charge (pH 7.0)-1.48

Net Charge (pH 7.4) -1.73

Charge Density (pH 7.0) -0.0449

GRAVY Index-2.02

Hydrophobic Moment 0.69

Boman Index-0.49

Instability Index70.51

Aliphatic Index 47.27

Aromaticity 0.0909

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1843.47

LogP -13.18

H-bond Donors 62.0

H-bond Acceptors 61.0

Rotatable Bonds 158.0

Heavy Atoms 297.0

Ring Count 5.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0399835 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 HXB2 | TZM-bl cells

Activity0.0009±0.0004 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0400309 VERIFIED: YES