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MYP_009668
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Basic Information
[N9G] Vc1.1
Miscellaneous
Standard
16 amino acids
C69H103N21O25S4
Standard
Sequence
GCCSDPRCGYDHPEIC
Physicochemical Analysis
1754.94 Da
4.54
-2.19
-2.50
-0.1368
-0.61
0.38
-0.10
35.26
24.38
0.0625
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
725.18
-9.31
28.0
28.0
51.0
119.0
4.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0064493 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
2-8; 3-16
Bio-Activity Profile
Nicotinic acetylcholine receptor antagonist
rat α9α10 nicotinic acetylcholine receptor
6 (4-11) nM
IC50
PaperScanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor PMID19447885 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22058133/
RECORD: Rec_0431767 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
2-8; 3-16
Bio-Activity Profile
Nicotinic acetylcholine receptor antagonist
human α9/rat α10 hybrid nicotinic acetylcholine receptor
28 (4-214) nM
IC50
PaperScanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor PMID19447885
RECORD: Rec_0431768 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
2-8; 3-16
Bio-Activity Profile
Nicotinic acetylcholine receptor antagonist
rat α3β2 nicotinic acetylcholine receptor
≥3000 nM
IC50
PaperScanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor PMID19447885
RECORD: Rec_0431769 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
2-8; 3-16
Bio-Activity Profile
Nicotinic acetylcholine receptor antagonist
rat α3β4 nicotinic acetylcholine receptor
≥3000 nM
IC50
PaperScanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor PMID19447885
RECORD: Rec_0431770 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
2-8; 3-16
Bio-Activity Profile
Nicotinic acetylcholine receptor antagonist
rat α7 nicotinic acetylcholine receptor
≥3000 nM
IC50
PaperScanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor PMID19447885