Peptide Database

Peptide NameHuman thrombin

Function Ontology

Hemostasis ▸ Anticoagulant activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length622 amino acids

Chemical FormulaC3066H4754N874O941S35

DescriptionStandard

        MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
    

Molecular Weight70036.11 Da

Isoelectric Point (pI)5.64

Net Charge (pH 7.0)-12.49

Net Charge (pH 7.4) -13.93

Charge Density (pH 7.0) -0.0201

GRAVY Index-0.54

Hydrophobic Moment 0.81

Boman Index-0.07

Instability Index40.88

Aliphatic Index 69.77

Aromaticity 0.0900

Extinction Coeff. Reduced 108290.00

Extinction Coeff. Oxidized 109915.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0426010 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyCoagulation factor

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Coagulation factor replacement Enzyme replacement

Half-LifeApproximately 60h [A19411].

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