MYP_009591
Human thrombin
Hemostasis
▸
Anticoagulant activity
Therapeutic / Biomedical activity
▸
Enzyme replacement therapy
Standard
622 amino acids
C3066H4754N874O941S35
Standard
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
70036.11 Da
5.64
-12.49
-13.93
-0.0201
-0.54
0.81
-0.07
40.88
69.77
0.0900
108290.00
109915.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0022500
VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Cricetulus griseus [Animal]
Coagulation factor
9606;10029
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Coagulation factor replacement
Due to the nature of the product, which is intended for topical application to the surface of the tissue at the surgical site, pharmacokinetic studies were not conducted [FDA Label].
RECORD: Rec_0075179
VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Cricetulus griseus [Animal]
Coagulation factor
9606;10029
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Coagulation factor replacement
Enzyme replacement
CHO
Following intravenous administration, thrombin alfa exhibited an initial half-life of 0.17 hours (10.2 min) [L2079]. Following either intravenous or subcutaneous administration, the agent demonstrated a terminal half-life of about 15 hours [L2079]. This data follows administration of thrombin alfa to cynomolgus monkeys.
RECORD: Rec_0115909
VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Coagulation factor
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Coagulation factor replacement
Approximately 60h [A19411].
RECORD: Rec_0357686
VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Coagulation factor
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Coagulation factor replacement
Anticoagulant
Approximately 60h [A19411].
RECORD: Rec_0406498
VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Cricetulus griseus [Animal]
Coagulation factor
9606;10029
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Coagulation factor replacement
CHO
Following intravenous administration, thrombin alfa exhibited an initial half-life of 0.17 hours (10.2 min) [L2079]. Following either intravenous or subcutaneous administration, the agent demonstrated a terminal half-life of about 15 hours [L2079]. This data follows administration of thrombin alfa to cynomolgus monkeys.
Showing 5 records on this page · Page 1 of 2