Peptide Database

Peptide NameC5a

Function Ontology

Immunology ▸ Immune cell migration ▸ Chemotactic peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length74 amino acids

Chemical FormulaC350H584N108O107S8

DescriptionStandard

        TLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGR
    

Molecular Weight8273.56 Da

Isoelectric Point (pI)8.93

Net Charge (pH 7.0)4.51

Net Charge (pH 7.4) 4.09

Charge Density (pH 7.0) 0.0610

GRAVY Index-0.38

Hydrophobic Moment 0.62

Boman Index-0.15

Instability Index53.93

Aliphatic Index 77.84

Aromaticity 0.0405

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3535.95

LogP -39.73

H-bond Donors 130.0

H-bond Acceptors 122.0

Rotatable Bonds 287.0

Heavy Atoms 573.0

Ring Count 6.0

Amide Bonds 80.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0355375 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Receptor agonist Chemotactic Immunomodulatory Signaling peptide

TargetC5a1 receptor (Human); C5a2 receptor (Human); C3a receptor (Human)

Activity2.5-9.5 nM

MethodIC50