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MYP_009380
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C119H207N27O28S2
Standard
Sequence
FLPILASLAATLGPKLLCLITKKC
Physicochemical Analysis
2528.21 Da
9.39
2.74
2.50
0.1141
1.30
0.49
0.41
30.12
158.75
0.0417
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
853.79
-3.09
31.0
33.0
82.0
176.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0252323 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Candida albicans (weak activity)
PaperPubMed PMID: 14531844 PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
RECORD: Rec_0256623 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ.M. Conlon et al. / J. Peptide Res. 62 (2003) 207-213. Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii Evidence URLhttps://www.uniprot.org/uniprotkb/P84113/entry
RECORD: Rec_0265813 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-positive Cytolytic Non-hemolytic
Gram-positive bacteria
PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
RECORD: Rec_0287285 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0314119 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
>50 μM
MIC
PaperIsolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii
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