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MYP_009267
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
41 amino acids
C164H260N58O54S10
Standard
Sequence
QTCASRCPRPCNAGLCCSIYGYCGSGNAYCGAGNCRCQCRG
Physicochemical Analysis
4228.82 Da
8.62
3.66
3.30
0.0892
-0.20
0.53
-0.06
3.37
28.78
0.0732
4470.00
5095.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1814.40
-29.89
74.0
68.0
131.0
286.0
5.0
45.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0115366 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Pyroglutamate
3-17; 7-37; 11-23; 16-30; 35-39
Bio-Activity Profile
Antimicrobial Antifungal
Fusarium moniliforme
56 μg/mL
IC50
PaperPubMed PMID: 12067732 PMID12067732 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12067732/
RECORD: Rec_0137961 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Plant]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
3-17; 7-37; 11-23; 16-30; 35-39
Bio-Activity Profile
Antimicrobial Antifungal
Phytophthora infestans
PMID12067732 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12067732/
RECORD: Rec_0155388 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Plant]
Hevein
Structure & Mods
linear peptide with five disulfide bonds [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
3-17; 7-37; 11-23; 16-30; 35-39
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antifungal
Ascochyta lycopersici
155 μg/mL
IC50
PaperPubMed PMID 12067732 PMID12067732 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12067732/
RECORD: Rec_0164905 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Plant]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
3-17; 7-37; 11-23; 16-30; 35-39
The N-terminus of the peptide is blocked by pyroglutamate. This is the first finding of a plant antifungal peptide with a five-disulfide motif. The five S-S bonds are C1-C5, C2-C9, C3-C6, C4-C7, and C8-C10. EAFP1 and EAFP2 show characteristics of hevein domain and exhibit chitin-binding properties similar to the previously identified hevein-like peptides. They exhibit relatively broad spectra of antifungal activities against eight pathogenic fungi from cotton, wheat, potato, tomato and tobacco
Bio-Activity Profile
Antifungal
antifungal growth-inhibition assay panel
PaperTwo novel antifungal peptides distinct with a five-disulfide motif from the bark of Eucommia ulmoides Oliv. PMID12067732
RECORD: Rec_0165425 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Plant]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
3-17; 7-37; 11-23; 16-30; 35-39
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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