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MYP_009221
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Basic Information
PGLa-St2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
22 amino acids
C90H155N25O25S
Standard
Sequence
GMATKAGTAFGKAAKAIIGAAL
Physicochemical Analysis
2019.41 Da
10.30
2.76
2.55
0.1253
0.78
0.57
0.36
3.58
89.55
0.0455
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
792.94
-8.45
28.0
29.0
68.0
141.0
1.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0096749 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic Toxicity
to erythrocytes
>256 μM
HC50
PaperOrigin and functional diversification of an amphibian defense Peptide arsenal. PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0101384 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Staphylococcus aureus ATCC 25923
256 μM
MIC
PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0164162 VERIFIED: YES
Provenance & Taxonomy
Silurana tropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli
16 μM
MIC
RECORD: Rec_0194835 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Trypanosoma brucei[90-100% Killing = 16-32 microM
PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0221394 VERIFIED: YES
Provenance & Taxonomy
Silurana tropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Sacharomyces cerevisiae
64 μM
MIC
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