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MYP_009221
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Basic Information
PGLa-St2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
22 amino acids
C90H155N25O25S
Standard
Sequence
GMATKAGTAFGKAAKAIIGAAL
Physicochemical Analysis
2019.41 Da
10.30
2.76
2.55
0.1253
0.78
0.57
0.36
3.58
89.55
0.0455
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
792.94
-8.45
28.0
29.0
68.0
141.0
1.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005237 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0024681 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 31.8%, E 0.0%, T 59.1%, C 9.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiparasitic Toxic Antimicrobial Antifungal Anti-Gram-positive Cytotoxic Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0035724 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
S. cerevisiae
64 μM
MIC
PaperOrigin and functional diversification of an amphibian defense Peptide arsenal. PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0063159 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
Staphylococcus aureus
>256 μM
MIC
PaperOrigin and functional diversification of an amphibian defense Peptide arsenal. PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0066292 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Pseudomonas aeruginosa ATCC 15692
128 μM
MIC
PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
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