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MYP_009184
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Basic Information
TAT-Cd0
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Standard
11 amino acids
C58H114N32O13S
Standard
Sequence
GRKKRRQRRRC
Physicochemical Analysis
1499.80 Da
12.00
7.75
7.53
0.7044
-3.29
0.49
-1.66
212.45
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
820.85
-11.09
34.0
22.0
57.0
104.0
0.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015957 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral
Exert antiviral activity by cell protection
0.4 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells. | Larsen IV, Brandt CR. | J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7. | DOI:10.1089/jop.2010.0076 | PMID:21029018 PMID21029018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21029018/
RECORD: Rec_0052722 VERIFIED: NO
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Fluorophore labeling
C-term detail: Labelled with fluorescein
Bio-Activity Profile
Cell-penetrating peptide
HeLa
Fluorescence-based uptake assay
RECORD: Rec_0107820 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Fluorescein labeling
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0164796 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral
Exert antiviral activity by inhibitng attachment
3 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells. | Larsen IV, Brandt CR. | J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7. | DOI:10.1089/jop.2010.0076 | PMID:21029018 PMID21029018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21029018/
RECORD: Rec_0173982 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Entry inhibition
Exert antiviral activity by entry block
0.1 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells. | Larsen IV, Brandt CR. | J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7. | DOI:10.1089/jop.2010.0076 | PMID:21029018 PMID21029018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21029018/
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