Peptide Database

Peptide NameAntimicrobial peptide THP2 (Turkey heterophil peptide 2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length64 amino acids

Chemical FormulaC335H518N90O79S8

DescriptionStandard

        MRILYLLFSLLFLALQVSPGLSSPKRDMLFCKRGTCHFGRCPSHLIKVGSCFGFRSCCKWPWDA
    

Molecular Weight7326.77 Da

Isoelectric Point (pI)9.55

Net Charge (pH 7.0)6.61

Net Charge (pH 7.4) 6.20

Charge Density (pH 7.0) 0.1033

GRAVY Index0.34

Hydrophobic Moment 0.67

Boman Index0.13

Instability Index61.98

Aliphatic Index 85.31

Aromaticity 0.1406

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2663.74

LogP -18.73

H-bond Donors 102.0

H-bond Acceptors 96.0

Rotatable Bonds 234.0

Heavy Atoms 512.0

Ring Count 17.0

Amide Bonds 64.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0272830 VERIFIED: YES

Provenance & Taxonomy

OrganismMeleagris gallopavo [other]

FamilyBeta-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus spp.

RECORD: Rec_0282998 VERIFIED: YES