MYP_009161
Dostarlimab
Anticancer
Immunology
▸
Immune modulation
▸
Immunomodulatory activity
Immunology
▸
Immunomodulation
▸
Immuno-oncology
Standard
443 amino acids
C2160H3324N566O675S17
Standard
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVSTISGGGSYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASPYYAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
48565.99 Da
6.74
-0.63
-1.44
-0.0014
-0.39
0.55
0.02
49.15
67.43
0.1016
76780.00
77405.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0311543
VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Monoclonal antibody
Structure & Mods
disulfide-constrained antibody chain backbone [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Immunomodulatory
Immuno-oncology
The mean terminal elimination half-life of dostarlimab is 25.4 days.[L33320]
RECORD: Rec_0431785
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Monoclonal antibody
Structure & Mods
disulfide-constrained antibody chain backbone [Linear]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported, sites unresolved
Bio-Activity Profile
Anticancer
Immuno-oncology
PD-1 antagonist
human PD-1
0.3 nM
SPR (KD)
RECORD: Rec_0431786
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Monoclonal antibody
Structure & Mods
disulfide-constrained antibody chain backbone [Linear]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported, sites unresolved
Bio-Activity Profile
Anticancer
Immuno-oncology
PD-1 antagonist
human PD-1 expressed on CHO-K1 cells
2.0 nM
flow-cytometry binding assay (EC50)
RECORD: Rec_0431787
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Monoclonal antibody
Structure & Mods
disulfide-constrained antibody chain backbone [Linear]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported, sites unresolved
Bio-Activity Profile
Anticancer
Immunomodulatory
Immuno-oncology
PD-1 antagonist
human CD4+ T cells; PD-1 pathway
~1 nM
mixed lymphocyte reaction (EC50; IL-2 readout)