Peptide Database

Peptide NameDostarlimab

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immuno-oncology

Standard StatusStandard

Sequence Length443 amino acids

Chemical FormulaC2160H3324N566O675S17

DescriptionStandard

        EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVSTISGGGSYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASPYYAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
    

Molecular Weight48565.99 Da

Isoelectric Point (pI)6.74

Net Charge (pH 7.0)-0.63

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.0014

GRAVY Index-0.39

Hydrophobic Moment 0.55

Boman Index0.02

Instability Index49.15

Aliphatic Index 67.43

Aromaticity 0.1016

Extinction Coeff. Reduced 76780.00

Extinction Coeff. Oxidized 77405.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0187764 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyMonoclonal antibody

Structure & Mods

Configcyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immuno-oncology

Half-LifeThe mean terminal elimination half-life of dostarlimab is 25.4 days.[L33320]

RECORD: Rec_0311543 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyMonoclonal antibody

Structure & Mods

Configcyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Immuno-oncology

Half-LifeThe mean terminal elimination half-life of dostarlimab is 25.4 days.[L33320]

RECORD: Rec_0402537 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMonoclonal antibody

Tax ID32630

Structure & Mods

Configcyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immuno-oncology

Half-LifeThe mean terminal elimination half-life of dostarlimab is 25.4 days.[L33320]