Peptide Database

Peptide NameDrotrecogin alfa

Function Ontology

Enzyme / Catalytic activity ▸ Protease ▸ Cytoprotective serine protease

Hemostasis ▸ Anticoagulant activity

Standard StatusStandard

Sequence Length242 amino acids

Chemical FormulaC1209H1892N334O353S12

DescriptionStandard

        LIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAP
    

Molecular Weight27138.76 Da

Isoelectric Point (pI)6.06

Net Charge (pH 7.0)-4.39

Net Charge (pH 7.4) -5.25

Charge Density (pH 7.0) -0.0181

GRAVY Index-0.24

Hydrophobic Moment 0.68

Boman Index0.04

Instability Index44.67

Aliphatic Index 91.41

Aromaticity 0.0785

Extinction Coeff. Reduced 52940.00

Extinction Coeff. Oxidized 53315.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084145 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyActivated protein C

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticoagulant Cytoprotective serine protease

Half-Life5.5 h (Mammalian reticulocytes,in vitro