Peptide Database

Peptide NameSLAY-screened peptide P4053

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC125H174N30O29

DescriptionStandard

        TLFYITHGHTLKRAYWYNYI
    

Molecular Weight2560.90 Da

Isoelectric Point (pI)9.40

Net Charge (pH 7.0)1.57

Net Charge (pH 7.4) 1.27

Charge Density (pH 7.0) 0.0784

GRAVY Index-0.28

Hydrophobic Moment 0.36

Boman Index0.16

Instability Index23.72

Aliphatic Index 83.00

Aromaticity 0.3000

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 961.99

LogP -3.45

H-bond Donors 36.0

H-bond Acceptors 33.0

Rotatable Bonds 76.0

Heavy Atoms 184.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0062318 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/