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MYP_009083
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Basic Information
LEDGF 361-370[N361A]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
11 amino acids
C58H92N14O18
Standard
Sequence
WASLKIDNLDV
Physicochemical Analysis
1273.43 Da
4.21
-1.24
-1.44
-0.1126
0.18
0.07
0.16
-20.01
141.82
0.0909
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
534.05
-3.27
18.0
17.0
41.0
90.0
2.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0030701 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1
PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
RECORD: Rec_0060690 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
Sup-T1
76 %
Inhibition
PaperMechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
RECORD: Rec_0159181 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0296681 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
0.1 μM
% inhibition
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperMechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. | Hayouka Z, Levin A, Maes M, Hadas E, Shalev DE, Volsky DJ, Loyter A, Friedler A. | Biochem Biophys Res Commun. 2010 Apr 2;394(2):260-5. | DOI:10.1016/j.bbrc.2010.02.100 | PMID:20171172 PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/
RECORD: Rec_0310306 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1[70-80% IN activity = 19.5 microM
PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/