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MYP_009082
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Basic Information
Bacillistatin 1
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
12 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XVXVXVXVXVXV
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0431735 VERIFIED: YES
Provenance & Taxonomy
Streptomyces fulvissimus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
cyclododecadepsipeptide; mixed L/D residues
Bio-Activity Profile
Anticancer Cytotoxic
NCI-H460 lung cancer cells
0.0025 μg/mL
GI50
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154
RECORD: Rec_0431736 VERIFIED: YES
Provenance & Taxonomy
Streptomyces fulvissimus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
cyclododecadepsipeptide; mixed L/D residues
Bio-Activity Profile
Anticancer Cytotoxic
KM20L2 colon cancer cells
0.0008 μg/mL
GI50
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154
RECORD: Rec_0431737 VERIFIED: YES
Provenance & Taxonomy
Streptomyces fulvissimus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
cyclododecadepsipeptide; mixed L/D residues
Bio-Activity Profile
Anticancer Cytotoxic
DU-145 prostate cancer cells
0.0035 μg/mL
GI50
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154
RECORD: Rec_0431738 VERIFIED: YES
Provenance & Taxonomy
Bacillus silvestris [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
cyclodepsipeptide
Bio-Activity Profile
Antimicrobial activity tested; inactive at 64 μg/mL
Cryptococcus neoformans ATCC 90112
>64 μg/mL
MIC (no inhibition at 64 μg/mL)
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154
RECORD: Rec_0431739 VERIFIED: YES
Provenance & Taxonomy
Bacillus silvestris [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
cyclodepsipeptide
Bio-Activity Profile
Antimicrobial activity tested; inactive at 64 μg/mL
Candida albicans ATCC 90028
>64 μg/mL
MIC (no inhibition at 64 μg/mL)
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154
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