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MYP_009082
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Basic Information
Bacillistatin 1
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
12 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XVXVXVXVXVXV
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0186151 VERIFIED: YES
Provenance & Taxonomy
Bacillus silvestris [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x=2R-hydroxy-3S-methyl-valeryl-R-valine; X=S-lactic acid-S-Val
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MCF-7 breast cancer cells
0.00061 μg/mL
GI50
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19226154/
RECORD: Rec_0232217 VERIFIED: YES
Provenance & Taxonomy
Streptomyces fulvissimus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x=R-Hiv; X=S-lactic acid-S-Val
Bio-Activity Profile
Antimicrobial Anticancer
BXPC-3 pancreatic cancer cells
0.0019 μg/mL
GI50
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19226154/
RECORD: Rec_0357212 VERIFIED: NO
Provenance & Taxonomy
Bacillus silvestris [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x(1/9)=2R-hydroxy-3S-methyl-valeryl-R-valine; x(5)=2R-hydroxy-4-methyl-valeryl-R-valine; X=S-lactic acid-S-Val
Bio-Activity Profile
Antimicrobial Anticancer
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19226154/
RECORD: Rec_0387918 VERIFIED: YES
Provenance & Taxonomy
Bacillus silvestris [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
x(1/9)=2R-hydroxy-3S-methyl-valeryl-R-valine; x(5)=2R-hydroxy-4-methyl-valeryl-R-valine; X=S-lactic acid-S-Val
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MCF-7 breast cancer cells
0.00031 μg/mL
GI50
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19226154/
RECORD: Rec_0431704 VERIFIED: YES
Provenance & Taxonomy
Bacillus silvestris [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
cyclodepsipeptide
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus pneumoniae ATCC 6303
4 μg/mL
MBC
PaperAntineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris PMID19226154
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