Peptide Database

Peptide NameConantokin-R

Function Ontology

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC123H203N35O41S3

DescriptionStandard

        GEEEVAKMAAELARENIAKGCKVNCYP
    

Molecular Weight2924.33 Da

Isoelectric Point (pI)5.07

Net Charge (pH 7.0)-1.25

Net Charge (pH 7.4) -1.50

Charge Density (pH 7.0) -0.0463

GRAVY Index-0.44

Hydrophobic Moment 0.68

Boman Index-0.08

Instability Index61.12

Aliphatic Index 68.89

Aromaticity 0.0370

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1244.00

LogP -12.44

H-bond Donors 43.0

H-bond Acceptors 43.0

Rotatable Bonds 100.0

Heavy Atoms 202.0

Ring Count 2.0

Amide Bonds 28.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0330008 VERIFIED: YES

Provenance & Taxonomy

OrganismConus radiatus [Animal]

Structure & Mods

Configlinear peptide; DSSP H 37.0%, E 14.8%, T 25.9%, C 22.2% [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Disulfide21-25

Other Modsgamma-carboxyglutamate (Gla) residues at positions 3, 4, 11, 15

Bio-Activity Profile

Function

NMDA receptor antagonist Neuroactive

TargetNMDA receptor

Activity93 nM

MethodIC50 ([3H]MK-801 binding inhibition)