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MYP_008941
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Basic Information
Cytotoxic linear peptide IsCT2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C73H108N16O16
Standard
Sequence
IFGAIWNGIKSLF
Physicochemical Analysis
1465.74 Da
8.75
0.76
0.55
0.0584
1.14
0.51
0.58
-12.43
127.69
0.2308
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
517.65
-1.11
18.0
17.0
46.0
105.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023367 VERIFIED: YES
Provenance & Taxonomy
Opisthacanthus madagascariensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 6538
3.4 μM
MIC
PMID12054688;28657596 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054688/
RECORD: Rec_0032565 VERIFIED: YES
Provenance & Taxonomy
Opisthacanthus madagascariensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID12054688;28657596 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054688/
RECORD: Rec_0040830 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
50 μg/mL
MIC
PMID28657596 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28657596/
RECORD: Rec_0053748 VERIFIED: YES
Provenance & Taxonomy
Opisthacanthus madagascariensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
50 μg/mL
MIC
PMID12054688;28657596 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054688/
RECORD: Rec_0062388 VERIFIED: YES
Provenance & Taxonomy
Opisthacanthus madagascariensis [Animal]
IsC
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Insecticidal
PaperJ Nat Prod. 2010 Jul 23;73(7):1207-13. | http://www.ncbi.nlm.nih.gov/pubmed/20575512 PMID20575512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20575512/
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