Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length359 amino acids

Chemical FormulaC1778H2819N477O514S17

DescriptionStandard

        MVWIVTVVLLFLSSHTICTNPALKARVTQQALDYGRQVGMQVLQEELKKINIPDVSGSTHVSVIGKVHYQISGIRIQAFSIAQSTVAFSPGTGMKLSLDNTNIAIHGNWRVKYSLGRDSGSFDVSVNGFSVSALIGMSTDQTGRPAVKSMGCSSNVGSLRLKLHGGASWLYNLFRSSLEKPIHSALVREICPKVSEAINSLDLKLQRLKVTANVDKIAEIDYFLVNPPVITETFMDLDFKGEFYNIGRHQEPPFTAGPLSFPEQTNHMMYLAVSEFFFNSAAFVYHRAGALQINITDSMIPKSSPIRLNTSTFGGFIPQLKKLYPEMLMLMKIHSLKQPALTMTSDNITIAMTGRSEEH
    

Molecular Weight39646.39 Da

Isoelectric Point (pI)9.12

Net Charge (pH 7.0)6.46

Net Charge (pH 7.4) 5.57

Charge Density (pH 7.0) 0.0180

GRAVY Index0.03

Hydrophobic Moment 0.68

Boman Index0.11

Instability Index39.01

Aliphatic Index 93.40

Aromaticity 0.0836

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30035.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0336063 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinchus milii [Animal]

FamilyBPI/LBP

Tax ID7868

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence