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MYP_008841
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Basic Information
Retrocyclin 1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
18 amino acids
C74H136N30O19S6
Standard
Sequence
GICRCICGRGICRCICGR
Physicochemical Analysis
1942.45 Da
9.01
3.70
3.41
0.2056
0.74
0.66
-0.05
-4.71
86.67
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
805.62
-10.02
37.0
29.0
65.0
129.0
0.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0098345 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
RECORD: Rec_0128628 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Retrocyclin
9606.0
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV Replication inhibitor
HIV-1 subtype B strains
0.66 μM
IC50
PaperRetrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1; Patent: Retrocyclins: Antiviral and Antimicrobial Peptides PMID11854483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11854483/ PatentUS 2009/0264344 A1
RECORD: Rec_0138821 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 B | JC53-BL cells
4.15±0.99 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRetrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 | Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI. | J Immunol. 2004 Jul 1;173(1):515-20. | DOI:10.4049/jimmunol.173.1.515 | PMID:15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
RECORD: Rec_0198186 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0233250 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 CRF01_AE | JC53-BL cells
5.33±0.8 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRetrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 | Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI. | J Immunol. 2004 Jul 1;173(1):515-20. | DOI:10.4049/jimmunol.173.1.515 | PMID:15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
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