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MYP_008841
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Basic Information
Retrocyclin 1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
18 amino acids
C74H136N30O19S6
Standard
Sequence
GICRCICGRGICRCICGR
Physicochemical Analysis
1942.45 Da
9.01
3.70
3.41
0.2056
0.74
0.66
-0.05
-4.71
86.67
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
805.62
-10.02
37.0
29.0
65.0
129.0
0.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024948 VERIFIED: YES
Provenance & Taxonomy
Primates [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Backbone-cyclized theta-defensin scaffold
Bio-Activity Profile
Antiviral Entry inhibitor
Herpes simplex virus 2 (Virus entry); ME-180
MTT assay
PaperTheta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. | Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring AJ, Herold BC, Wagar EA, Lehrer RI. | J Virol. 2004 | PMID:15113897 PMID15113897 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113897/
RECORD: Rec_0037480 VERIFIED: NO
Provenance & Taxonomy
Silent gene [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0040319 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Evidence URLhttps://patents.google.com/patent/US20090264344A1/en PatentUS 2009/0264344 A1
RECORD: Rec_0067564 VERIFIED: YES
Provenance & Taxonomy
Primates [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Backbone-cyclized theta-defensin scaffold
Bio-Activity Profile
Antiviral Entry inhibitor
Herpes simplex virus 1 (Virus entry); ME-180
MTT assay
PaperTheta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. | Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring AJ, Herold BC, Wagar EA, Lehrer RI. | J Virol. 2004 | PMID:15113897 PMID15113897 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113897/
RECORD: Rec_0073299 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 BF | JC53-BL cells
7.24 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRetrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 | Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI. | J Immunol. 2004 Jul 1;173(1):515-20. | DOI:10.4049/jimmunol.173.1.515 | PMID:15210812 PMID15210812 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15210812/
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