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MYP_008832
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Basic Information
Geobacillin I (nisin analog; Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
33 amino acids
C136H238N40O46S8
Standard
Sequence
VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC
Physicochemical Analysis
3426.10 Da
8.27
1.66
1.35
0.0504
0.74
0.33
0.16
45.33
85.45
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1384.99
-20.97
56.0
56.0
111.0
230.0
1.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0205315 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Cyclization
Four lanthionines (S3-C7,S23-C27,S26-C30,S29-C33) and three β-methyllanthionines (T8-C11; T13-C18; T20-C24),S5 is dehydroalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Methicillin-resistant Staphylococcus aureus C5
2.23±0.03 μM
IC50
PaperPubMed PMID: 22431611 PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0211548 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Cyclization
Four lanthionines (S3-C7,S23-C27,S26-C30,S29-C33) and three β-methyllanthionines (T8-C11; T13-C18; T20-C24),S5 is dehydroalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis ATCC 6633
0.55±0.01 μM
IC50
PaperPubMed PMID: 22431611 PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0220859 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans NG80-2 [other]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Methicillin-resistant Staphylococcus aureus C5
2.23± 0.03 μM
IC50
PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0228414 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22497806 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22497806/
RECORD: Rec_0231454 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Cyclization
Four lanthionines (S3-C7,S23-C27,S26-C30,S29-C33) and three β-methyllanthionines (T8-C11; T13-C18; T20-C24),S5 is dehydroalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus lactis HP ATCC 11602
0.12±0.09 μM
IC50
PaperPubMed PMID: 22431611 PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
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