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MYP_008832
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Basic Information
Geobacillin I (nisin analog; Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
33 amino acids
C136H238N40O46S8
Standard
Sequence
VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC
Physicochemical Analysis
3426.10 Da
8.27
1.66
1.35
0.0504
0.74
0.33
0.16
45.33
85.45
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1384.99
-20.97
56.0
56.0
111.0
230.0
1.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0032556 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Cyclization
Four lanthionines (S3-C7,S23-C27,S26-C30,S29-C33) and three β-methyllanthionines (T8-C11; T13-C18; T20-C24),S5 is dehydroalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Vancomycin-resistant Enterococcusfaecium CNRZ 481
0.84±0.05 μM
IC50
PaperPubMed PMID: 22431611 PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0120229 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Cyclization
Four lanthionines (S3-C7,S23-C27,S26-C30,S29-C33) and three β-methyllanthionines (T8-C11; T13-C18; T20-C24),S5 is dehydroalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Streptococcus dysgalatiae subsp dysgalactiae ATCC 27957
0.69±0.05 μM
IC50
PaperPubMed PMID: 22431611 PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0131403 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans NG80-2 [other]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus anthracis Sterne 7702
0.49
IC50
PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
RECORD: Rec_0195560 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperLantibiotics from Geobacillus thermodenitrificans.
RECORD: Rec_0196891 VERIFIED: YES
Provenance & Taxonomy
Geobacillus thermodenitrificans NG80-2 [other]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus lactis HP ATCC 11602
0.12
IC50
PMID22431611 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22431611/
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