Peptide Database

Peptide NameFactor XIII (human)

Function Ontology

Hemostasis ▸ Fibrinolytic activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length694 amino acids

Chemical FormulaC3542H5468N960O1053S28

DescriptionStandard

        GVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM
    

Molecular Weight79244.92 Da

Isoelectric Point (pI)5.74

Net Charge (pH 7.0)-11.00

Net Charge (pH 7.4) -12.25

Charge Density (pH 7.0) -0.0158

GRAVY Index-0.38

Hydrophobic Moment 0.97

Boman Index-0.01

Instability Index35.09

Aliphatic Index 79.96

Aromaticity 0.1081

Extinction Coeff. Reduced 125710.00

Extinction Coeff. Oxidized 126210.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0241782 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyCoagulation factor

Tax ID9606;4932

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Coagulation factor replacement Enzyme replacement Thrombolytic Fibrinolytic

Half-Life6.6 ±2.29 days [FDA Label], 6.6 days [A32364]

RECORD: Rec_0431697 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyFactor XIII A chain

Structure & Mods

Configlinear protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Coagulation factor Transglutaminase Fibrin cross-linking

TargetFibrin

Methodthrombin activation / fibrin cross-linking assay