Peptide Database

Peptide NameFactor XIII (human)

Function Ontology

Hemostasis ▸ Fibrinolytic activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length694 amino acids

Chemical FormulaC3542H5468N960O1053S28

DescriptionStandard

        GVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM
    

Molecular Weight79244.92 Da

Isoelectric Point (pI)5.74

Net Charge (pH 7.0)-11.00

Net Charge (pH 7.4) -12.25

Charge Density (pH 7.0) -0.0158

GRAVY Index-0.38

Hydrophobic Moment 0.97

Boman Index-0.01

Instability Index35.09

Aliphatic Index 79.96

Aromaticity 0.1081

Extinction Coeff. Reduced 125710.00

Extinction Coeff. Oxidized 126210.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0241782 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]

FamilyCoagulation factor

Tax ID9606;4932

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Coagulation factor replacement Enzyme replacement Thrombolytic Fibrinolytic

Half-Life6.6 ±2.29 days [FDA Label], 6.6 days [A32364]