Peptide Database

Peptide NameSLAY-screened peptide P5359

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC104H164N22O29S

DescriptionStandard

        PCTYSTHLLYEPLLLTLLQ
    

Molecular Weight2218.61 Da

Isoelectric Point (pI)5.25

Net Charge (pH 7.0)-0.96

Net Charge (pH 7.4) -1.09

Charge Density (pH 7.0) -0.0507

GRAVY Index0.54

Hydrophobic Moment 0.25

Boman Index0.32

Instability Index45.99

Aliphatic Index 143.68

Aromaticity 0.1053

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 794.79

LogP -3.56

H-bond Donors 29.0

H-bond Acceptors 30.0

Rotatable Bonds 67.0

Heavy Atoms 156.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0233690 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/