Peptide Database

Peptide NameTP4-1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC135H243N41O27

DescriptionStandard

        FIIIKKSGGLFKKKAGARKKKRIKK
    

Molecular Weight2872.63 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)11.75

Net Charge (pH 7.4) 11.53

Charge Density (pH 7.0) 0.4700

GRAVY Index-0.76

Hydrophobic Moment 0.57

Boman Index-0.34

Instability Index11.38

Aliphatic Index 86.00

Aromaticity 0.0800

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1165.95

LogP -7.51

H-bond Donors 43.0

H-bond Acceptors 39.0

Rotatable Bonds 112.0

Heavy Atoms 203.0

Ring Count 2.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0087544 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus

Activity>25 μM

MethodMIC

PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/

RECORD: Rec_0170734 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity100 μM

MethodHemolysis

PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/

RECORD: Rec_0216412 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetAcinetobacter baumannii

Activity>25 μM

MethodMBC

PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/

RECORD: Rec_0226930 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus

Activity>25 μM

MethodMBC

PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/

RECORD: Rec_0280107 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetAcinetobacter baumannii

Activity>25 μM

MethodMIC

PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/