Peptide Database

Peptide Namealpha-conotoxin MII analog P6A

Function Ontology

Miscellaneous

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC65H104N22O23S4

DescriptionStandard

        GCCSNAVCHLEHSNLC
    

Molecular Weight1689.91 Da

Isoelectric Point (pI)5.98

Net Charge (pH 7.0)-1.10

Net Charge (pH 7.4) -1.47

Charge Density (pH 7.0) -0.0689

GRAVY Index0.29

Hydrophobic Moment 0.31

Boman Index0.12

Instability Index25.04

Aliphatic Index 73.12

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 721.12

LogP -10.68

H-bond Donors 28.0

H-bond Acceptors 28.0

Rotatable Bonds 53.0

Heavy Atoms 114.0

Ring Count 2.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417366 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 12.5%, T 56.2%, C 31.2% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Miscellaneous

PaperConoServer: updated content, knowledge, and discovery tools in the conopeptide database; Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors PMID22058133;15044624 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22058133/ PatentUS7387997B2