Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length481 amino acids

Chemical FormulaC2401H3744N616O676S19

DescriptionStandard

        MDFAYRLTLLFSIAAFVGTADAENPGLVVRVTQKGLDYALQEGVIALQQQLSHIQLKDISGTYGLGFLGHANYKFFSMNLGNVQLPGFQVSPIPNVGLKLSTSGGFFEVNGRWDVRYSFIHEDGTFNLKVGGLGMSIGLNLRNIEHGKPTVSVADCSCRIANVEVHMSGTIGWLVELFHGAVESEIRKELENKICPEVNKFINSDVSSFLRNQPVNKKIDHISGLDYSLMGPPSVMANWVDVFVKGKFYGMSHIHHPPIFAPPLTPPAMSLPPEQDHMVYFAVSDYVFNTALLTYQRAGALVLTLTDNMIPKKFGIHLDTNLLQRVIPSVSKMYPNMPMKLEMSAASTPALNINPGGVTLSPVGNIQAYAILPNSSLAPLFLLQAKMNALAKVAVNSGKIVGSLELGKVEISLVHSDVGLFSVSVISMAVNYYVSATLLPRVNEILKNGFPLPLIDHIQLTDFVIETYEHYLLFGANAHYE
    

Molecular Weight52664.37 Da

Isoelectric Point (pI)6.34

Net Charge (pH 7.0)-4.09

Net Charge (pH 7.4) -5.27

Charge Density (pH 7.0) -0.0085

GRAVY Index0.19

Hydrophobic Moment 0.71

Boman Index0.20

Instability Index43.75

Aliphatic Index 102.91

Aromaticity 0.0936

Extinction Coeff. Reduced 41830.00

Extinction Coeff. Oxidized 41955.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0198066 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis (Western clawed frog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria