Peptide Database

Peptide NameR-spondin-4

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length215 amino acids

Chemical FormulaC1018H1645N339O300S22

DescriptionStandard

        LNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
    

Molecular Weight24138.47 Da

Isoelectric Point (pI)9.42

Net Charge (pH 7.0)20.92

Net Charge (pH 7.4) 20.14

Charge Density (pH 7.0) 0.0973

GRAVY Index-0.91

Hydrophobic Moment 0.75

Boman Index-0.27

Instability Index55.47

Aliphatic Index 48.09

Aromaticity 0.0605

Extinction Coeff. Reduced 22460.00

Extinction Coeff. Oxidized 23835.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0030543 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPhosphorylation of tyrosine residue at position 93; asparagine residue at position 15 is N-linked glycosylated; disulfide bonds between cysteine residues at positions 120 and 162; 131 and 138; 171 and 177

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetLGR4 (Human); LGR5 (Human); LGR6 (Human)

Activity0.09 nM

MethodEC50